The PCR instrument that optimizes every sample automatically

Thermocyclers run one, pre-set program for every well. iconPCR™ instruments monitor amplification in real time and automatically stop each reaction at its optimal endpoint.

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Standard Thermal Cycling

Amplification follows a pre-set number of cycles. Some samples are over-amplified, others are under-amplified. The resulting concentration and quality varies widely.

AutoNorm with iconPCR

In Slope mode, amplification of each individual well automatically stops and enters a cold hold once the exponential threshold is reached.

PCR optimization shouldn’t be trial and error

Overcycling

Creates artifacts, bias, and wasted sequencing reads.

Undercycling

Causes sample dropout and poor library yields.

Manual Optimization

Consumes time and precious samples.

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With iconPCR, optimization is automated.Here’s how it works:

First, we built a better box

Each well of the icon instrument features an individual, miniaturized thermocycler with real-time temperature monitoring.

Then, we made it smart

AutoNorm™ intelligent software automates cycle control by monitoring concentration in real time using fluorescence, and placing each well on a cold hold at just the right time.

The Result:

Fewer artifacts
More consistent yields
Less trouble shooting
Better reproducibility

A game changer for genomics

Produce sequencing-ready libraries for WGS/WES, RNA-seq, single cell, metagenomics, and clinical applications with no manual normalization.

Eliminates dropout
Reduces chimeras
Balances libraries
Accelerates workflows

Traditional Thermocycler

One program for all wells

Fixed cycle count

Manual normalization

Multiple QC steps

Variable library yields

iconPCR

Independent control per well

Rea-time adaptive cycling

AutoNormalization

Single cleanup

Sequencing-ready libraries

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Essential for assay development

Design, Optimize, Repeat — Without the Wait
iconPCR empowers assay development with true Design of Experiments (DOE) flexibility: 96 wells, 96 independent PCR conditions, on one plate. Eliminate split-plot headaches, test gradients and reagent tweaks side-by-side, and slice hands-on time by up to 80%. AutoNorm makes every well count, delivering real data for smarter assay iteration and rapid optimization. Get your answers (and your weekends) back, while saving time and consumables — all in a single, streamlined run.

Download the DOE tech note