Products | iconPCR™ Platform — icon96 & icon16 | n6

The iconPCR™ Platform —
Adaptive Amplification for Every Lab.

iconPCR brings real-time adaptive amplification to NGS library prep with AutoNorm™. One platform, two instruments — choose the format that fits your lab.

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icon96 and icon16 side by side
The Technology

One Platform. Two Technologies Working Together.

The Instrument Platform

iconPCR

The world's first thermocycler with individually controlled wells. iconPCR brings real-time temperature monitoring and independent amplification control to every well — simultaneously. Available in two formats: icon96 and icon16.

iconPCR gives you direct control over how much DNA you make — not just how many cycles you run.
The Adaptive Engine

AutoNorm

AutoNorm is the closed-loop amplification control system inside every iconPCR instrument. It monitors real-time fluorescence in each well and stops amplification the moment a sample reaches its user-defined optimal endpoint — automatically, per well, no fixed cycle count.

Amplify. Quantify. Normalize. All at once.
✓
Each well stops independently — no fixed cycle count required
✓
Libraries balanced during PCR, not corrected after
✓
Works with your existing reagents, kits, and sequencing platforms
✓
Eliminates individual quantification and normalization steps
See AutoNorm in Action

🎬 Software Demo Video

Coming Soon — End of May

Software walkthrough — approx. 2 min
Choose Your Format

Same AutoNorm Performance. Optimized for Your Scale.

Both instruments deliver the full AutoNorm experience. The difference is throughput and deployment model.

icon96

icon96

High throughput. High complexity. No problem.

icon96 is purpose-built for centralized sequencing environments that need to process large sample volumes reliably, across variable inputs, at scale.

Batch Size
1–96 samples per run
Consumable Format
Standard full-skirt 96-well plates
Best For
WGS, bulk RNA-seq, metagenomics, targeted oncology panels, population genomics
Deployment
Shared instrument — supports multiple research groups
Automation
Automation-ready with full RESTful API and headless mode
For: Genomics cores, academic sequencing centers, CROs, large pharma and biotech
Learn about Automation
icon16

icon16

Small footprint. Small budget. Big impact.

icon16 brings the full AutoNorm standard to labs running smaller sequencing batches — no compromise on data quality, no waiting to fill a plate.

Batch Size
1–16 samples per run
Consumable Format
n6 8-well strips (2 × 8, provided by n6)
Best For
Single-cell RNA-seq, spatial transcriptomics, cfDNA/MRD, rare disease sequencing, assay development
Deployment
Dedicated bench instrument — run samples when ready
Automation
Optimized for manual workflows
For: PI labs, translational research groups, clinical research programs, smaller sequencing facilities

icon16 requires n6 8-well strips for warranty coverage.

View icon16 FAQ
At a Glance
icon96 icon16
Wells per run9616 (2 × 8 strips)
Typical batch size48–96 samples8–16 samples
AutoNorm✓✓
Real-time per-well monitoring✓✓
Deployment modelShared / core facilityDedicated / lab bench
Automation ready✓ Full RESTful APIManual workflows preferred
Proven Across Leading Labs

Used in 22+ Countries.
Trusted by the World's Top Genomics Programs.

Deployed at the Broad Institute, Wellcome Sanger Institute, UCSF, MIT BioMicro Center, SciLifeLab Sweden, and more.
AutoNorm software showing 33 samples

"There are not many technologies that from the outset can significantly impact established workflows. But with AutoNorm technology we're able to fundamentally change how PCR is approached in library preparation."

— James Docker, NGS Lead & Multi-Omics Scientist, University of Oxford

"Redoing samples that drop out is costly — with iconPCR, you avoid that issue. If you're working with precious sample, knowing that you'll get enough library each time is also reassuring and a big benefit."

— Eric Chow, Associate Professor, UCSF
Universal Compatibility

Fits Into Your Workflow — No Changes Required.

iconPCR is sequencer-agnostic, reagent-agnostic, and designed to replace PCR in your existing workflow — nothing else needs to change.

✓
Open chemistry — no proprietary reagents; add SYBR Green or EvaGreen to your existing PCR mix
✓
Compatible with all major sequencing platforms: Illumina, PacBio, Element, Ultima
✓
Works with all major commercial library prep kits — no protocol changes needed
✓
No upstream workflow modifications required
✓
ISO 13485-compliant manufacturing
✓
Standard lab power (100–240V); compact benchtop footprint
✓
icon96: full-skirt 96-well plates; 10–100 µL volumes
✓
icon16: n6 8-well strips; 10–100 µL volumes
Consumables

What You'll Need to Run

iconPCR runs with a small set of validated consumables — available directly from n6.

96-Well Plates

96-Well Full-Skirt Plates

Compatible with: icon96

Recommended for best AutoNorm performance
and plate-deck compatibility.

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8-Well Strips

8-Well Strips

Compatible with: icon16

Required for warranty coverage.
Only n6 strips are supported on icon16.

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Ready to See It in Action?

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